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SML1466

ABH hydrochloride

≥98% (HPLC), arginase inhibitor, powder

Synonym(s):

2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride

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Size/SKUAvailabilityPrice
5 mg
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$209.00
25 mg
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$796.00

About This Item

Empirical Formula (Hill Notation):
C6H14BNO4 · HCl
CAS Number:
Molecular Weight:
211.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$209.00


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Product Name

ABH hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +8 to +13°, c = 0.7 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OB(O)CCCC[C@H](N)C(O)=O.[H]Cl

InChI

1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1

InChI key

XCUVEZUCSHVMRK-JEDNCBNOSA-N

Biochem/physiol Actions

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.
ABH is a highly potent and specific arginase inhibitor
Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

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This Item
SML1384SML0698SML0574
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 5 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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