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SML1478

Ophiobolin A

≥95% (HPLC)

Synonym(s):

(2′S,3′S,3aR,5′R,6aS,9R,9aS,10aR)-1,3a,4,4′,5′,6a,7,8,9,9a,10,10a-Dodecahydro-9-hydroxy-3′,9,10a-trimethyl-5′-spiro[dicyclopenta[a,d]cyclooctene-3(2H),2′(3′H)-furan]-6-carboxaldehyde

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Size/SKUAvailabilityPrice
100 μg
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$103.00
$87.55
1 mg
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$406.00

About This Item

Empirical Formula (Hill Notation):
C25H36O4
CAS Number:
Molecular Weight:
400.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
protect from light

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biological source

(from Biopolaris leersia fungal metabolite)

Quality Segment

assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

storage temp.

−20°C

SMILES string

[H]C(/C1=C/C[C@]([C@]2(O[C@@H](C=C(C)C)C[C@@H]2C)CC3)([H])[C@@]3(C)C[C@@]([C@](C)(O)C4)([H])[C@]1([H])C4=O)=O

InChI

1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22+,23+,24+,25-/m0/s1

InChI key

MWYYLZRWWNBROW-BDZRSQQBSA-N

Biochem/physiol Actions

Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.
Ophiobolin A is a fungal metabolite; calmodulin antagonist with anticancer activity.

Other Notes

Light and air sensitive.

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This Item
PHL80440442543927082
description

≥95% (HPLC)

description

phyproof® Reference Substance

description

analytical standard

description

≥95%

form

powder

form

-

form

-

form

powder

assay

≥95% (HPLC)

assay

≥95.0% (HPLC)

assay

-

assay

≥95%

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

-

storage temp.

2-30°C

storage temp.

2-8°C

storage condition

protect from light

storage condition

-

storage condition

-

storage condition

-

color

white to beige

color

-

color

-

color

-


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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