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SML1522

Doxofylline

≥98% (HPLC)

Synonym(s):

7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione, 7-(1,3-Dioxolan-2-ylmethyl)theophylline

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$90.20

About This Item

Empirical Formula (Hill Notation):
C11H14N4O4
CAS Number:
Molecular Weight:
266.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$90.20


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CN1C2=C(N(CC3OCCO3)C=N2)C(N(C)C1=O)=O

InChI

1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3

InChI key

HWXIGFIVGWUZAO-UHFFFAOYSA-N

General description

Doxofylline is a novel xanthine derivative comprising of dioxolone group.

Application

Doxofylline has been used as a phosphodiesterase (PDE) inhibitor to study its protective effects on lipopolysaccharides (LPS)-induced inflammatory response in human pulmonary bronchial epithelial cells. It has also been used to study its interaction with bovine serum albumin (BSA).

Biochem/physiol Actions

Doxofylline acts and as a non-selective phosphodiesterase (PDE) inhibitor and exhibits anti-inflammatory activity. It has the potential to treat chronic obstructive pulmonary disease (COPD).
Doxofylline (also known as doxophylline) has antitussive and bronchodilator effects. Doxofylline is used clinically in the treatment of asthma. Doxofylline has similar efficacy to theophylline, but unlike theophylline or other xanthines has little affinity for adenosine receptors and does not produce stimulant effects and has significantly fewer side effects.

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This Item
D0633SML1142T1633
description

≥98% (HPLC)

description

-

description

≥98% (HPLC)

description

anhydrous, ≥99%, powder

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥99%

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: slightly soluble 8.3 mg/ml, NH4OH: 50 mg/ml, clear, colorless, alcohol: 12.5 mg/ml, chloroform: soluble 9.1 mg/ml, 0.1 M HCl: soluble, 0.1 M NaOH: soluble, ammonium hydroxide: soluble, aqueous base: soluble, diethyl ether: slightly soluble, dilute HCl: soluble, dilute nitric acid: soluble, ethanol: moderately soluble

color

white to beige

color

-

color

white to beige

color

white


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. Is it a secondary reference standart?

    1 answer
    1. This product is not a secondary reference standard. It is intended for use in general laboratory research applications. Currently, this compound is not available as secondary reference standard.

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