SML1539
TDFA trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-L-ornithinamide trifluoroacetate salt, Thr-Asp-F-amidine trifluoroacetate salt
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $345.00 |
25 mg | Check Cart for Availability | $1,410.00 |
About This Item
Empirical Formula (Hill Notation):
C17H29FN6O7 · xC2HF3O2
Molecular Weight:
448.45 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
shipped in
dry ice
storage temp.
−70°C
General description
TDFA trifluoroacetate salt or tripeptide F-amidine analog is a derivative synthesized to increase the selectivity, bioavailability and potency of Cl-amidine, which is a member of protein arginine deiminases (PADs) compounds.
Biochem/physiol Actions
Selective inhibitor of PAD4 (peptidyl arginine deiminase 4)
TDFA (Thr-Asp-F-amidine) is a selective inhibitor of peptidyl arginine deiminase 4 (protein arginine deiminase 4, PAD4 or PADI4), a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline, a process called citrullination. PAD4 is upregulated in cancer and inflammatory diseases, and may be involved in rheumatoid arthritis onset and progression. It has recently been found to be involved in the regulation of pluripotency: important for stem-cell gene activation, induced pluripotent stem (iPS) cell reprogramming, and maintenance of pluripotent cells in the early mouse embryo. TDFA has an IC50 value of 2.3 μM and is ≥15-fold selective for PAD4 versus PAD1 and ≥50-fold selective versus PADs 2 and 3.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description >98% (HPLC) | description ≥95% (HPLC), powder | description ≥98% (HPLC) |
| form powder | form lyophilized powder | form powder | form powder |
| assay ≥98% (HPLC) | assay >98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 10 mg/mL, clear | solubility H2O: >2 mg/mL | solubility H2O: ≥2 mg/mL | solubility - |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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