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SML1701

BX430

≥98% (HPLC)

Synonym(s):

N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N′-(3-pyridinyl)urea

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$310.00

About This Item

Empirical Formula (Hill Notation):
C15H15Br2N3O
CAS Number:
Molecular Weight:
413.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$310.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O

InChI

1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)

InChI key

JFNKIJKRXKPQCC-UHFFFAOYSA-N

Biochem/physiol Actions

BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels.
BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNS, and have been studied as a therapeutic target for neuropathic pain and inflammation, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. BX430 is highly selective for human P2X4, with minimal activity towards other P2X subtypes, including P2X1–P2X3, P2X5, and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 receptors. BX430 has an IC50 value of 540 nM.

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This Item
SML0298SML0355N2540
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: >10 mg/mL

solubility

DMSO: >30 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

white to faint yellow


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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