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SML1767

Sparstolonin B

≥98% (HPLC)

Synonym(s):

4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one, Sparstolenin B, SsnB

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Size/SKUAvailabilityPrice
5 mg
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$125.00
25 mg
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$511.00

About This Item

Empirical Formula (Hill Notation):
C15H8O5
CAS Number:
1259330-61-4
Molecular Weight:
268.22
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$125.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3

InChI

1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H

InChI key

DHSASSJDMAHICE-UHFFFAOYSA-N

Biochem/physiol Actions

Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties
Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.

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Sparstolonin B ≥98% (HPLC)

Sigma-Aldrich

SML1767

Sparstolonin B

Splitomicin ≥98% (HPLC), powder

Sigma-Aldrich

S4068

Splitomicin

NSC756093 ≥98% (HPLC)

Sigma-Aldrich

SML1310

NSC756093

Sauchinone ≥98% (HPLC)

Sigma-Aldrich

SML0783

Sauchinone

description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

-

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

-

color

white to beige

color

white to beige

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Questions

  1. Can IP injections of Sparstolonin B cross the blood-brain barrier into the neuroparenchyma in mice?

    1 answer

    1. This product is not tested for in vivo use. However, a literature review indicates that SsnB can cross the blood-brain barrier.

      Kindly review the following publications:

      Zhong Q, Zhou K, Liang QL, Lin S, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Yang YR, Liao MF, Gong QW, Liu L, Xiong A, Hao J, Wang J, Yang QW. Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral Hemorrhage. J Am Heart Assoc. 2016 Oct 11;5(10):e004340. doi: 10.1161/JAHA.116.004340. PMID: 27729335; PMCID: PMC5121525.

      Wang Y, Jiang S, Xiao J, Liang Q, Tang M. Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice. Exp Ther Med. 2018 Jun;15(6):5436-5442. doi: 10.3892/etm.2018.6092. Epub 2018 Apr 24. PMID: 29844805; PMCID: PMC5958797.

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