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SML1778

SR0987

≥98% (HPLC)

Synonym(s):

2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl)benzamide

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onAugust 10, 2026fromMILWAUKEE

$106.00
$90.10
25 mg

Estimated to ship onAugust 10, 2026fromMILWAUKEE

$434.00

About This Item

Empirical Formula (Hill Notation):
C16H10ClF6NO2
CAS Number:
Molecular Weight:
397.70
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$90.10

List Price$106.00Save 15%
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Estimated to ship onAugust 10, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)NC(=O)c2c(cccc2)Cl

InChI key

IZVBONMVWLTLNT-UHFFFAOYSA-N

Biochem/physiol Actions

SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC50 ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes.
SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency.

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This Item
SML0322G7423SML2820
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), white to off-white, powder

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >5 mg/mL

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to off-white

color

white to beige


pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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