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SML1781

PDD00017273

≥98% (HPLC), powder, poly(ADP-ribose) glycohydrolase inhibitor

Synonym(s):

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$147.00
25 mg

Available to ship TODAYfromMILWAUKEE

$560.00

About This Item

Empirical Formula (Hill Notation):
C23H26N6O4S2
CAS Number:
Molecular Weight:
514.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$147.00


Available to ship TODAYDetails


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Product Name

PDD00017273, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC5(CC5)C)c1cc2c([n]([c]([n]([c]2=O)Cc4[s]c(nc4)C)=O)Cc3[n](nc(c3)C)C)cc1

InChI key

IFWUBRBMMNTBRZ-UHFFFAOYSA-N

Biochem/physiol Actions

PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs).
PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG has been shown to be involved in the repair of single strand DNA breaks. PDD00017273 is selective for PARG, with EC50 = 26 nM, compared to values of 30 μM for PARP1 and ARH3.
PDD00017273 is cell permeable in nature. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).

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This Item
SRP8023HPA041247HPA021819
description

≥98% (HPLC)

description

recombinant, expressed in Sf21 cells, His tagged, >95% (SDS-PAGE)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

form

powder

form

liquid

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

assay

≥98% (HPLC)

assay

>95% (SDS-PAGE)

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

-10 to -25°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

water: soluble

solubility

-

solubility

-

color

white to beige

color

clear

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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