Skip to Content
MilliporeSigma

Skip To

SML1812

IMR-1

≥98% (HPLC)

Synonym(s):

2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester, Inhibitor of Mastermind Recruitment-1

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$130.00

About This Item

Empirical Formula (Hill Notation):
C15H15NO5S2
CAS Number:
Molecular Weight:
353.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$130.00


Available to ship TODAYDetails


​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC

InChI

1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)

InChI key

QHPJWPQRZMBKTG-UHFFFAOYSA-N

Application

Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells.

Biochem/physiol Actions

IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.
IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
CB_96020931SML2767CB_85020204
vibrant-m

IMR-33

description

≥98% (HPLC)

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

description

≥98% (HPLC)

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 85020204, human lung (fetal), Fibroblast

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−196°C

storage temp.

2-8°C

storage temp.

−196°C

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

H2O: 2 mg/mL, clear

solubility

-

color

white to beige

color

-

color

white to beige

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters