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SML1839

PFM39

≥98% (HPLC)

Synonym(s):

(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone, 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one

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Size/SKUAvailabilityPrice
5 mg
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$147.00

About This Item

Empirical Formula (Hill Notation):
C10H9N3OS
CAS Number:
Molecular Weight:
219.26
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$147.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1

InChI

1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-

InChI key

QXOIZYPBCJHYLN-YVMONPNESA-N

Biochem/physiol Actions

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity.
PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

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This Item
SML1735M9948PLA0057
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

Powered by Bethyl Laboratories, Inc.

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

form

powder

form

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >10 mg/mL

solubility

-

color

yellow to orange

color

white to beige

color

red to orange

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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