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SML1977

J113863, cis isomer

>97% (HPLC)

Synonym(s):

1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide, Piperidinium, 1-(1-cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethyl-, iodide (1:1), cis-

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5 mg
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$104.00
$88.40
25 mg
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$415.00

About This Item

Empirical Formula (Hill Notation):
C30H37Cl2IN2O2
CAS Number:
Molecular Weight:
655.44
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
>97% (HPLC)
Form:
powder

$88.40

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assay

>97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C30H36Cl2N2O2.HI/c1-2-34(20-21-8-6-4-3-5-7-9-21)16-14-24(15-17-34)33-30(35)29-25-18-22(31)10-12-27(25)36-28-13-11-23(32)19-26(28)29;/h8,10-13,18-19,24,29H,2-7,9,14-17,20H2,1H3;1H/b21-8+;/t24-,34+;

InChI key

FOAFBMYSXIGAOX-KEKKVSGZSA-N

Biochem/physiol Actions

High affinity antagonist for CCR1 and CCR3 receptors, agonist at CCR2 and CCR5 receptors
J113863 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both J113863 and its enantiomer c exhibit low binding affinity toward CCR2 and CCR5 where they activate three Gi and two G0 protein isoforms. J113863 does not activate G12 protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

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This Item
SML2832SML1975SML2807
description

>97% (HPLC)

description

≥98% (HPLC)

description

>97% (HPLC)

description

≥98% (HPLC)

assay

>97% (HPLC)

assay

≥98% (HPLC)

assay

>97% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

faint red to dark brown

color

white to beige

color

faint yellow to dark orange


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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