Key Documents

Tiotropium bromide monohydrate

Name: Tiotropium bromide monohydrate
Brand: SIGMA

≥98% (HPLC), NF-κB activation inhibitor, powder

Synonym(s):

(1α, 2β, 4 β, 5α, 7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate, 3-Oxa-9-azoniatricyclo[3.3.1.02,4]?nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, hydrate (1:1:1), (1α,2β,4β,5α,7β), 6β,7β-epoxy-3β-hydroxy-8-methyl-1αH,5αH-tropanium bromide monohydrate, di-2-thienylglycolate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₂BrNO₄S₂ · H₂O

CAS Number:

411207-31-3

Molecular Weight:

490.43

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD23704176

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Tiotropium bromide monohydrate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[H]O[H].O=C(C(C1=C([H])C([H])=C([H])S1)(O[H])C2=C([H])C([H])=C([H])S2)O[C@@]3([H])C([H])([H])[C@@]4([H])[C@@]5([H])[C@@](O5)([H])[C@](C3([H])[H])([H])[N+]4(C([H])([H])[H])C([H])([H])[H].[Br-]

InChI

1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16?,17?;;

InChI key

MQLXPRBEAHBZTK-YQMLGFMRSA-M

Description

Application

Tiotropium bromide monohydrate may be used as a long-acting muscarinic receptor antagonist (LAMA) in a comparative study to explore its efficacy in the downregulation of the cough reflex in rabbits.[1]

Biochem/physiol Actions

Tiotropium Bromide is an anticholinergic bronchodilator. It is considered a long-acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for chronic obstructive pulmonary disease (COPD) and asthma.

Tiotropium bromide exhibits more beneficial effects on pulmonary function than other anticholinergic and β-2 adrenergic agents. Tiotropium can prevent the proliferation of fibroblasts and myofibroblasts induced by acetylcholine. It can block human monocyte chemotaxis.

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1 of 1

This Item	SML2372	SML2385	SMB00806
Sigma-Aldrich SML2008 Tiotropium bromide monohydrate	Sigma-Aldrich SML2372 β-Muricholic Acid	Sigma-Aldrich SML2385 Andrastin A	Sigma-Aldrich SMB00806 7-Ketodeoxycholic acid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
form powder	form powder	form powder	form powder
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility -	solubility -
color white to beige	color white to beige	color white to beige	color off-white to beige

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000361549

0000202010

0000154224

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Global Trade Item Number

SKU	GTIN
SML2008-50MG	04061835502875
SML2008-5MG	04061833247860
SML2008-10MG	04061835502868
SML2008-25MG	04061833247853

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