SML2100
RIPA-56
≥98% (HPLC)
Synonym(s):
N-Benzyl-N-hydroxy-2,2-dimethylbutanamide, RIPA56
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $63.00 |
25 mg | Check Cart for Availability | $193.00 |
About This Item
Empirical Formula (Hill Notation):
C13H19NO2
CAS Number:
Molecular Weight:
221.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
N(O)(Cc1ccccc1)C(=O)C(CC)(C)C
InChI
1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
InChI key
AVYVHIKSFXVDBG-UHFFFAOYSA-N
Biochem/physiol Actions
Highly potent and selective receptor interacting protein 1 kinase (RIP1; RIPK1) type III inhibitor with in vitro and in vivo efficacy against necroptosis.
RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50 = 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.
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This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description affinity isolated antibody, buffered aqueous solution | description ≥95% (HPLC), powder |
| form powder | form buffered aqueous solution | form powder |
| assay ≥98% (HPLC) | assay - | assay ≥95% (HPLC) |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility DMSO: >20 mg/mL, H2O: insoluble |
| color white to beige | color - | color off-white to yellow |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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