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SML2151

MBX2546

≥98% (HPLC)

Synonym(s):

N-(3,5-Dimethylphenyl)-2-(N-(2-methyl-5-nitrophenyl)methylsulfonamido)acetamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$93.00
25 mg

Available to ship TODAYfromMILWAUKEE

$376.00

About This Item

Empirical Formula (Hill Notation):
C18H21N3O5S
CAS Number:
695160-12-4
Molecular Weight:
391.44
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$93.00

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=C([N+]([O-])=O)C=C1N(S(C)(=O)=O)CC(NC2=CC(C)=CC(C)=C2)=O

InChI

1S/C18H21N3O5S/c1-12-7-13(2)9-15(8-12)19-18(22)11-20(27(4,25)26)17-10-16(21(23)24)6-5-14(17)3/h5-10H,11H2,1-4H3,(H,19,22)

InChI key

XPPCEUZUDQSVQO-UHFFFAOYSA-N

Biochem/physiol Actions

MBX2546 is a non-cytotoxic (CC50 >100 μM; 283T) molecule that inhibits against influenza hemagglutinin- (HA-) mediated viral entry (IC90 = 5.7 μM against HIV/HA(H5) entry in 293T culture vs. IC90 >100 μM, 98.2 μM, and >85 μM against HIV/LASV-GP, HIV/EBOV-GP, HIV/VSV-G, respectively) by targeting group 1 HA-specific conformational epitope in the HA stem loop region. MBX2546 is shown to inhibit influenza A strains A/PR/8/34 (H1N1) and A/Florida/21/2008 (H1N1-H275Ψ) (oseltamivir-resistant strain), A/California/10/2009/H1N1, as well as high pathogenic avian influenza (HPAI) strain A/Hong Kong/H5N1 (IC50 = 0.3, 5.8, 0.55-1.5, and 3.6 μM, respectively), but not A/Texas/12/2007 (H3N2), A/Perth/16/2009 (H3N2), A/Victoria/3/75 (H3N2), A/Panama/2007/99 (H3N2), A/Sydney/05/97 (H3N2), A/California/7/04 (H3N2), A/Wyoming/03/2003 (H3N2), or influenza B strain B/Florida/4/2006 in MDCK cultures.
Non-cytotoxic molecule that blocks hemagglutinin (HA)-mediated influenza A host entry by targeting group 1 HA stem loop region conformational epitope.

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MBX2546 ≥98% (HPLC)

Sigma-Aldrich

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Monoclonal Anti-Influenza A virus H1N1 NA (Neuraminidase) antibody produced in mouse clone GT288, affinity isolated antibody

Sigma-Aldrich

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Monoclonal Anti-Influenza A virus H1N1 NA (Neuraminidase) antibody produced in mouse

Anti-Influenza A Antibody, H1N1, clone 9B3.2 clone 9B3.2, Chemicon®, from mouse

Sigma-Aldrich

MAB8261

Anti-Influenza A Antibody, H1N1, clone 9B3.2

Anti-Influenza A Antibody, H1N1 Antigen, clone 9B3.2 ascites fluid, clone 9B3.2, Chemicon®

Sigma-Aldrich

MAB8256

Anti-Influenza A Antibody, H1N1 Antigen, clone 9B3.2

description

≥98% (HPLC)

description

clone GT288, affinity isolated antibody

description

clone 9B3.2, Chemicon®, from mouse

description

ascites fluid, clone 9B3.2, Chemicon®

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

buffered aqueous solution

form

-

form

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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