Cell-permeable factor XIIIa and transglutaminase 2 irreversible inhibitor that targets active site Cys for acetonylation with little GSH inhibitory potency.
R283 (NTU283; Rob283) is a cell-permeable 2-[(2-oxopropyl)thio] imidazolium derivative that acts as an irreversible inhibitor against factor XIIIa (FXIIIa) and transglutaminase 2 (TG2, TGase II) by targeting FXIIIa and TG2 active site cysteine (Cys) for acetonylation in a selective manner with little glutathione (GSH) inhibitory potency (app 2nd order rate const = 23000/M/s, 19000/M/s, 0.12/M/s, respectively). A useful tool for investigating TG2-mediated cellular functions (typical conc. range: 25-500 μM).
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.
assay
≥98% (HPLC)
assay
≥98% (HPLC)
assay
>99% (HPLC)
assay
≥95% (HPLC)
form
powder
form
powder
form
solid
form
solid
storage temp.
−20°C
storage temp.
2-8°C
storage temp.
2-8°C
storage temp.
2-8°C
solubility
H2O: 2 mg/mL, clear
solubility
-
solubility
DMSO: >20 mg/mL, H2O: insoluble
solubility
DMSO: 100 mg/mL, ethanol: 10 mg/mL
color
white to beige
color
white to beige
color
-
color
pale yellow
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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