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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Estimated to ship onOctober 05, 2026fromMILWAUKEE | $319.00 |
About This Item
Empirical Formula (Hill Notation):
C15H9Cl2FN4
CAS Number:
Molecular Weight:
335.16
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=C(C2=CC=C(NC3=NC(Cl)=NC(Cl)=N3)C=C2)C=C1
InChI
1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)
InChI key
DUROVTLUQOYUPH-UHFFFAOYSA-N
Biochem/physiol Actions
KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.
Thioredoxin-Caspase 3 interaction disruptor; apotosis inducer
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description - | description - |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (SDS-PAGE) |
| form powder | form lyophilized | form lyophilized solid |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility soluble (Reconstitute in physiological buffer containing 3 mM EDTA and 1-5 mM DTT.) |
| color white to beige | color - | color - |
KEA1-97 for biological assays | - | - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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