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SML2180

KEA1-97

≥98% (HPLC)

Synonym(s):

4,6-Dichloro-N-(4′-fluoro-[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship onOctober 05, 2026fromMILWAUKEE

$319.00

About This Item

Empirical Formula (Hill Notation):
C15H9Cl2FN4
CAS Number:
Molecular Weight:
335.16
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$319.00


Estimated to ship onOctober 05, 2026Details


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC=C(C2=CC=C(NC3=NC(Cl)=NC(Cl)=N3)C=C2)C=C1

InChI

1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)

InChI key

DUROVTLUQOYUPH-UHFFFAOYSA-N

Biochem/physiol Actions

KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.
Thioredoxin-Caspase 3 interaction disruptor; apotosis inducer

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This Item
SCP0097598101
description

≥98% (HPLC)

description

-

description

-

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (SDS-PAGE)

form

powder

form

lyophilized

form

lyophilized solid

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

soluble (Reconstitute in physiological buffer containing 3 mM EDTA and 1-5 mM DTT.)

color

white to beige

color

-

color

-

KEA1-97 for biological assays

-

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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