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SML2185

PA-6

≥98% (HPLC)

Synonym(s):

1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane, N,N′-[1,5-Pentanediylbis(oxy-4,1-phenylene)]bis-benzenecarboximidamide, Pentamidine-Analogue 6

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Size/SKUAvailabilityPrice
25 mg
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$400.00

About This Item

Empirical Formula (Hill Notation):
C31H32N4O2
CAS Number:
Molecular Weight:
492.61
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$400.00


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(C1=CC=CC=C1)NC(C=C2)=CC=C2OCCCCCOC3=CC=C(NC(C4=CC=CC=C4)=N)C=C3

InChI

1S/C31H32N4O2/c32-30(24-10-4-1-5-11-24)34-26-14-18-28(19-15-26)36-22-8-3-9-23-37-29-20-16-27(17-21-29)35-31(33)25-12-6-2-7-13-25/h1-2,4-7,10-21H,3,8-9,22-23H2,(H2,32,34)(H2,33,35)

InChI key

PETGITKEGWIZEL-UHFFFAOYSA-N

Biochem/physiol Actions

PA-6 (Pentamidine-Analogue 6) is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel.
selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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