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SML2210

AubipyOMe

≥97% (NMR)

Synonym(s):

(SP-4-2)-dichloro(4,4′-dimethoxy-2,2′-bipyridine-kN1,kN1′)-Gold(1+), hexafluorophosphate(1-), [Au(4,4′-dimethoxy-2,2′-bipyridine)Cl2][PF6]

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$113.00
25 mg

Available to ship TODAYfromMILWAUKEE

$454.00

About This Item

Empirical Formula (Hill Notation):
C12H12AuCl2N2O2 · PF6
CAS Number:
1221591-26-9
Molecular Weight:
629.07
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (NMR)
Form:
powder

$113.00

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assay

≥97% (NMR)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Cl-][Au+3]1([N]2=C(C=C(C=C2)OC)C3=[N]1C=CC(OC)=C3)[Cl-].F[P-](F)(F)(F)(F)F

Biochem/physiol Actions

AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5), a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts.
Tartrate resistant acid phosphatase (TRAP/ACP5) inhibitor

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AubipyOMe ≥97% (NMR)

Sigma-Aldrich

SML2210

AubipyOMe

(±)-Marinopyrrole A ≥95% (HPLC)

Sigma-Aldrich

SML1533

(±)-Marinopyrrole A

Hexachlorophene ≥95% (HPLC)

Sigma-Aldrich

SML3593

Hexachlorophene

(R)-(+)-5,5′-Dichloro-2,2′-bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl ≥95.0% (H-NMR)

Sigma-Aldrich

96738

(R)-(+)-5,5′-Dichloro-2,2′-bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl

assay

≥97% (NMR)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95.0% (H-NMR)

form

powder

form

powder

form

powder

form

crystals

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to beige

color

light yellow to dark yellow

color

white to beige

color

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000512941
0000512939
0000512939
0000512941
0000467045

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Carian E Boorsma et al.
Scientific reports, 7(1), 12570-12570 (2017-10-05)
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required to assess functional aspects of the protein. We
Shujun Yang et al.
Molecular medicine (Cambridge, Mass.), 30(1), 89-89 (2024-06-16)
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been shown to promote cell proliferation and phenotypic transition. However, it remains

Global Trade Item Number

SKUGTIN
SML2210-5MG04061835507719
SML2210-25MG04061835507702

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