Please see section 3 and section 15 of the Safety Data Sheet:
https://www.sigmaaldrich.com/sds/sigma/sml2231.
SML2231
Erasin
≥98% (HPLC)
Synonym(s):
(E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide, Erlotinib-resistance antagonizing STAT3 inhibitor
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Please contact Customer Service for Availability | $113.00 $96.05 | |
| 25 mg | Please contact Customer Service for Availability | $455.00 $386.75 |
About This Item
Empirical Formula (Hill Notation):
C20H19N3O3
CAS Number:
Molecular Weight:
349.38
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
$96.05
List Price$113.00Save 15%Web-Only Promotion
Please contact Customer Service for Availability
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31
InChI
1S/C20H19N3O3/c1-20(2,3)15-6-7-17-16(9-15)18(24)14(12-26-17)11-22-23-19(25)13-5-4-8-21-10-13/h4-12H,1-3H3,(H,23,25)/b22-11+
InChI key
JHUVYXUBEMYTNO-SSDVNMTOSA-N
Biochem/physiol Actions
Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner.
Selective inhibitor of STAT3
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: ≥20 mg/mL | solubility DMSO: 10 mg/mL, clear |
| color white to beige | color white to beige | color white to off-white | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2231-25MG | 04061838524300 |
| SML2231-5MG | 04061838524317 |
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I need a list of the percentage of ingredients in ERASI for products going to Canada. Required by health canada for personal care products.
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