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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Estimated to ship TODAYfromMILWAUKEE | $302.00 |
About This Item
Empirical Formula (Hill Notation):
C14H11NO5S2
CAS Number:
Molecular Weight:
337.37
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[s]1c(cc(c1C(=O)OC)NC(=O)C=CC(=O)O)c2[s]ccc2
InChI
1S/C14H11NO5S2/c1-20-14(19)13-8(15-11(16)4-5-12(17)18)7-10(22-13)9-3-2-6-21-9/h2-7H,1H3,(H,15,16)(H,17,18)
InChI key
GJODSFZNKNHKML-UHFFFAOYSA-N
Biochem/physiol Actions
HTS01037 is a selective, high-affinity fatty acid-binding protein FABP4 (AFABP; aP2) antagonist (aP2 Ki = 0.67 μM; EFABP/HF/IFABP/LFABP Ki = 3.40/9.07/6.57/8.17 μM) that targets aP2 long-chain fatty acid-binding site. HTS01037 is shown to downregulate basal and fatty acid-stimulated LTC4 levels in primary murine peritoneal macrophages (0.2-20 μM), upregulate murine macrophage RAW 264.7 intracellular free fatty acids and uncoupling protein 2 (UCP2) mRNA levels (30 μM), as well as suppress PPARγ target genes expression in IL-4 polarized human primary macrophages (10-25 μM).
Selective, high-affinity fatty acid-binding protein FABP4 (AFABP; aP2) antagonist that blocks aP2-mediated responses in human and murine macrophages.
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description C8 - C22, certified reference material, ampule of 100 mg (Neat) |
| form powder | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| storage temp. −20°C | storage temp. room temp | storage temp. -10 to -25°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility - |
| color white to beige | color white to light brown | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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