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SML2396

α-DHED

≥98% (HPLC)

Synonym(s):

alpha-DHED, 10β,17a-Dihydroxyestra-1,4-dien-3-one

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$122.00
$103.70
25 mg

Available to ship TODAYfromMILWAUKEE

$490.00
$416.50

About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
Molecular Weight:
288.38
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$103.70

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@H]4O)=CC(C=C1)=O

InChI key

UIKDFTLKOKNUJP-ZCVDQKGDSA-N

Biochem/physiol Actions

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer′s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.
Bioprecursor prodrug of 17α-estradiol that results in 17α-estradiol being produced selectively in the brain

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description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

Major secretory steroidal product of the adrenal gland.

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

10-30°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

ethanol: 20 mg/mL

color

white to beige

color

white to light brown

color

white to beige

color

off-white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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