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SML2401

Imeglimin hydrochloride

≥98% (HPLC), powder, anti-hyperglycemic compound

Synonym(s):

(6R)-1,6-dihydro-N,N,6-trimethyl-1,3,5-Triazine-2,4-diamine Hydrochloride,, (6R)-3,6-Dihydro-N2,N2,6-trimethyl-1,3,5-triazine-2,4-diamine, EMD 387008 Hydrochloride, EMD-387008 Hydrochloride, R-(4-Imino-6-methyl-1,4,5,6-tetrahydro-[1,3,5]trazin-2-yl)dimethylamine Hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$163.00
25 mg

Available to ship TODAYfromMILWAUKEE

$655.00

About This Item

Empirical Formula (Hill Notation):
C6H13N5 · xHCl
CAS Number:
Molecular Weight:
155.20 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$163.00


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Product Name

Imeglimin hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.N1[C@@H](N=C(N=C1N(C)C)N)C

InChI

1S/C6H13N5.ClH/c1-4-8-5(7)10-6(9-4)11(2)3;/h4H,1-3H3,(H3,7,8,9,10);1H/t4-;/m1./s1

InChI key

UXHLCYMTNMEXKZ-PGMHMLKASA-N

Biochem/physiol Actions

Glucose-lowering agent that appears to target mitochondrial bioenergetics
Imeglimin is a first-in-class oral glucose-lowering agent whose mechanism of action targets mitochondrial bioenergetics, resulting in increased insulin secretion in response to glucose, improved glucose uptake by skeletal muscle, and suppression of gluconeogenesis. Imeglimin has been shown to decrease reactive oxygen species overproduction and delay mPTP opening, preventing cell death during oxidative stress, protecting beta-cells. In an animal model, it has been shown to reduce metabolic syndrome-related diabetic cardiomyopathy.

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This Item
SML2631SML2386SML3192
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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