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SML2404

EC23

≥98% (HPLC)

Synonym(s):

4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid, 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid, AGN 190205, AGN-190205, AGN190205, BASF 46928, BASF-46928, BASF46928, EC 23, EC-23

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Size/SKUAvailabilityPrice
5 mg
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$76.60
25 mg
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$299.00
$254.15

About This Item

Empirical Formula (Hill Notation):
C23H24O2
CAS Number:
Molecular Weight:
332.44
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder

$76.60


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc(cc1)C#Cc2cc3c(cc2)C(CCC3(C)C)(C)C

InChI

1S/C23H24O2/c1-22(2)13-14-23(3,4)20-15-17(9-12-19(20)22)6-5-16-7-10-18(11-8-16)21(24)25/h7-12,15H,13-14H2,1-4H3,(H,24,25)

InChI key

OQVLOWLEEHYBJH-UHFFFAOYSA-N

Biochem/physiol Actions

EC23 is a synthetic, photostable all-trans retinoic acid (ATRA) analog/mimetic that targets RAR with greater affinity than ATRA (RARα/β/γ EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 μM) with a similar or better efficiency than ATRA.
Photostable all-trans retinoic acid (ATRA) mimetic that targets RAR with greater affinity and induces stem cells differentiation with better efficiency than ATRA.

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This Item
SML2665SML2034S7696
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

form

powder

form

buffered aqueous solution

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

color

white to beige

color

white to beige

color

white to beige

color

-


Pictograms

Health hazard

Signal Word

Warning

Hazard Codes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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