SML2408
UNC3866 trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $126.00 |
25 mg | Check Cart for Availability | $509.00 |
About This Item
Empirical Formula (Hill Notation):
C43H66N6O8
Molecular Weight:
795.02
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
lyophilized powder (white)
assay
≥98% (HPLC)
form
lyophilized powder (white)
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1
UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥95% (HPLC) | description >98% (HPLC) | description ≥95% (HPLC) |
| form lyophilized powder (white) | form lyophilized powder | form lyophilized powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay >98% (HPLC) | assay ≥95% (HPLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in wet ice | shipped in wet ice | shipped in - | shipped in wet ice |
| color white to off-white | color white to off-white | color white to tan | color white to off-white |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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