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SML2418

PS10

≥98% (HPLC)

Synonym(s):

2-[(2,4-Dihydroxyphenyl)sulfonyl]-2,3-dihydro-1H-isoindole-4,6-diol

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$136.00
$115.60

About This Item

Empirical Formula (Hill Notation):
C14H13NO6S
CAS Number:
1564265-82-2
Molecular Weight:
323.32
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$115.60

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=C(O)C=C(O)C=C1)(N2CC(C(O)=CC(O)=C3)=C3C2)=O

InChI

1S/C14H13NO6S/c16-9-1-2-14(13(19)4-9)22(20,21)15-6-8-3-10(17)5-12(18)11(8)7-15/h1-5,16-19H,6-7H2

InChI key

SVUZJWAAXPEMKJ-UHFFFAOYSA-N

Biochem/physiol Actions

PS10 is a potent and selective PDK (Pyruvate dehydrogenase kinase) inhibitor that improves glucose tolerance and lessens hepatic steatosis in diet-induced obese mice. PS10 binds to the ATP-binding pocket of PDKs.
potent and selective PDK (Pyruvate dehydrogenase kinase) inhibitor
2-[(2,4-dihydroxyphenyl) sulfonyl]isoindoline-4,6-diol (PS10) can be considered as a therapeutic method to preserve glucose and lipid homeostasis in obesity and type 2 diabetes (T2D). It can induce pyruvate dehydrogenase complex (PDC) activity in liver and kidney. It is also considered as an effective PDK inhibitor to treat diabetic cardiomyopathy. In the normal myocardium, PS10 helps to enhance fractional carbohydrate oxidation.

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This Item
SML0759H9415SML0140
PS10 ≥98% (HPLC)

Sigma-Aldrich

SML2418

PS10

L002 ≥98% (HPLC)

Sigma-Aldrich

SML0759

L002

5HPP-33 ≥98% (HPLC), solid

Sigma-Aldrich

H9415

5HPP-33

BV02 ≥98% (HPLC)

Sigma-Aldrich

SML0140

BV02

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), solid

description

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

DMSO: >5 mg/mL

color

white to beige

color

white to beige

color

white to off-white

color

white to off-white

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000053443
0000059049
0000059050
0000344235

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