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SML2434

TP-238 Hydrochloride

≥98% (HPLC)

Synonym(s):

1-(3-(6-(4-(3-dimethylamino-propoxy)-phenyl)-2-methylsulfonyl-pyrimidin-4-ylamino)-propyl)-1H-pyrazole Hydrochloride, N-(3-(1H-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$161.00
$136.85
25 mg

Available to ship TODAYfromMILWAUKEE

$649.00

About This Item

Empirical Formula (Hill Notation):
C22H30N6O3S · xHCl
Molecular Weight:
458.58 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$136.85

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

Chemical probe for CECR2/BPTF bromodomains
TP-238 is a chemical probe for CECR2 (cat eye syndrome chromosome region, candidate 2), a gene expressed in the nervous system involved in neurulation, and for BPTF bromodomains. It has an activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 showed an IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay and a KD of 10nM for CECR2 and 120nM for BPTF by ITC. The structurally related negative control TP-422 is completely inactive against BPTF and CECR2.

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This Item
SML1507SML2716SML0702
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated


Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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