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SML2457

Amgen16

≥98% (HPLC)

Synonym(s):

1-((1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)ethynyl)cyclopentanol, 1-[2-[1-(2-Amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]cyclopentanol, Amgen 16

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5 mg

Available to ship TODAYfromMILWAUKEE

$107.00
$90.95
25 mg

Available to ship TODAYfromMILWAUKEE

$435.00
$369.75

About This Item

Empirical Formula (Hill Notation):
C19H19ClN4O
CAS Number:
1202761-92-9
Molecular Weight:
354.83
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC=C(C(N2CCC3=C2C=C(C=C3)C#CC4(CCCC4)O)=N1)Cl

InChI

1S/C19H19ClN4O/c20-15-12-22-18(21)23-17(15)24-10-6-14-4-3-13(11-16(14)24)5-9-19(25)7-1-2-8-19/h3-4,11-12,25H,1-2,6-8,10H2,(H2,21,22,23)

InChI key

KJIQYGRWNLGGMI-UHFFFAOYSA-N

Biochem/physiol Actions

Amgen16 is an NF-κB-inducing kinase (NIK) inhibitor that selectively disrupts noncanonical NF-κB activation in U-2 OS cells (lymphotoxin β receptor LTβR-/TWEAK recetor FN14-mediated p52 nuclear translocation IC50 = 417 nM/2.517 μM) without affecting canonical NF-κB activation (TNF-α-stimulated p65 (RelA) nuclear translocation IC50 >30 μM). Likewise, Amgen16 (1 μM, 30 min pretreatment) selectively inhibits NFKB2 (p100) mRNA production upon noncanonical NF-κB activation (by 84%; 20 ng/mL TWEAK for 4 h), while exhibiting much smaller effect against canonical NF-κB stimulator-induced NFKB2 production (by 36%; 10 ng/mLTNFα for 4 h).
NF-κB-inducing kinase (NIK) inhibitor that selectively disrupts noncanonical over canonical NF-κB activation.

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Amgen16 ≥98% (HPLC)

Sigma-Aldrich

SML2457

Amgen16

GSK1838705A ≥98% (HPLC)

Sigma-Aldrich

SML0995

GSK1838705A

ASS234 ≥98% (HPLC)

Sigma-Aldrich

SML2769

ASS234

UPCDC30245 ≥98% (HPLC)

Sigma-Aldrich

SML1674

UPCDC30245

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 30 mg/mL, clear

color

white to beige

color

white to light brown

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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