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SML2465

CY-09

≥98% (HPLC)

Synonym(s):

4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onAugust 10, 2026fromMILWAUKEE

$118.00
$100.30
25 mg

Estimated to ship onAugust 10, 2026fromMILWAUKEE

$454.00
$385.90

About This Item

Empirical Formula (Hill Notation):
C19H12F3NO3S2
CAS Number:
Molecular Weight:
423.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$100.30

List Price$118.00Save 15%
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Estimated to ship onAugust 10, 2026Details


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assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C(C=C1)=CC=C1/C=C(SC2=S)\C(N2CC3=CC=CC(C(F)(F)F)=C3)=O)=O

InChI

1S/C19H12F3NO3S2/c20-19(21,22)14-3-1-2-12(8-14)10-23-16(24)15(28-18(23)27)9-11-4-6-13(7-5-11)17(25)26/h1-9H,10H2,(H,25,26)/b15-9+

InChI key

DJTINRHPPGAPLD-OQLLNIDSSA-N

Biochem/physiol Actions

CY-09 is an NLRP3 inflammasone inhibitor. CY-09 binds directly to the ATP-binding motif of NLRP3 NACHT domain and inhibits its ATPase activity, blocking NLRP3 inflammasome assembly and activation. In mouse models CY-09 showed therapeutic effects in type 2 diabetes and cryopyrin-associated auto-inflammatory syndrome (CAPS), which is caused by gain-of-function mutations of NLRP3.
NLRP3 inflammasome inhibitor

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This Item
SML2281SML2533SML0943
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

color

faint yellow to dark orange

color

white to beige

color

white to beige

color

orange to dark red


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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