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SML2468

CINPA1

≥98%

Synonym(s):

CAR Inhibitor not PXR Activator 1, Ethyl 5-(2-(diethylamino)acetyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-ylcarbamate, [5-[(Diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamic acid ethyl ester

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$95.70
$81.34
25 mg

Available to ship TODAYfromMILWAUKEE

$386.00
$328.10

About This Item

Empirical Formula (Hill Notation):
C23H29N3O3
CAS Number:
Molecular Weight:
395.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98%
Form:
powder

$81.34

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assay

≥98%

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(CN(CC)CC)N1C2=C(C=CC=C2)CCC3=C1C=C(NC(OCC)=O)C=C3

InChI

1S/C23H29N3O3/c1-4-25(5-2)16-22(27)26-20-10-8-7-9-17(20)11-12-18-13-14-19(15-21(18)26)24-23(28)29-6-3/h7-10,13-15H,4-6,11-12,16H2,1-3H3,(H,24,28)

InChI key

AYQBYSPEGRYKFA-UHFFFAOYSA-N

Biochem/physiol Actions

CINPA1 is a ligand-binding domain (LBD)-targeting constitutive androstane receptor (CAR) inhibitor that prevents CAR recruitment to promoter regions of regulated genes (by >85%; 1 μM CINPA1 against 0.1 μM CITCO-induced CAR recruitment to CYP2B6 or CYP3A4 promoters; human hepatocytes) by altering CAR-coregulator interactions. CINPA1 inhibits CAR-mediated transcription in a potent (IC50 = 70 nM; HepG2-hCAR1 CYP2B6-luc reporter cells) and selective manner with only weak PXR antagonist potency (68% inhibition by 18 μM CINPA1 against 5 μM rifampicin; HepG2-PXR reporter cells) and no cytotoxicity or agonist/antagonist activity toward FXR, GR, LXRα/β, PPARγ, RXRα/β, VDR.
Potent and selective ligand-binding domain (LBD)-targeting constitutive androstane receptor (CAR) inhibitor.

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This Item
I7379PHR1918O3764
description

≥98%

description

≥99% (TLC)

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

≥98% (HPLC), solid

assay

≥98%

assay

≥99% (TLC)

assay

-

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

solid

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 50 mg/mL

solubility

-

solubility

DMSO: ~9 mg/mL

color

white to beige

color

white

color

-

color

white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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