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SML2490

APC366 trifluoroacetate

≥97% (HPLC)

Synonym(s):

APC 366 trifluoroacetate, N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide, N2-[(1-Hydroxy-2-naphthalenyl)carbonyl]-L-arginyl-L-prolinamide trifluoroacetate

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Size/SKUAvailabilityPrice
5 mg
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$120.00
25 mg
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$301.00

About This Item

Empirical Formula (Hill Notation):
C22H28N6O4 · xC2HF3O2
CAS Number:
Molecular Weight:
440.50 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
lyophilized powder

$120.00


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assay

≥97% (HPLC)

form

lyophilized powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

SMILES string

FC(F)(C(O)=O)F.NC(NCCC[C@@H](C(N1CCC[C@H]1C(N)=O)=O)NC(C2=C(O)C3=CC=CC=C3C=C2)=O)=N

InChI

1S/C22H28N6O4/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26)/t16-,17-/m0/s1

InChI key

SKYWIMYOGAWOMB-IRXDYDNUSA-N

Biochem/physiol Actions

APC366 is a selective inhibitor of mast cell tryptase, which is involved with allergenic response. It thereby also inhibits protease-activated receptor PAR2, a G-protein-coupled receptor that is activated by mast cell tryptase. Tryptase has been proposed to be involved in fibrosis, joint inflammation and also in promoting breast cancer angiogenesis, all of which APC366 inhibited.
Mast cell tryptase inhibitor

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This Item
SML2973SML2962SML1374
description

≥97% (HPLC)

description

≥95% (HPLC)

description

≥94.5% (HPLC)

description

≥98% (HPLC)

form

lyophilized powder

form

film or powder

form

lyophilized powder

form

powder

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥94.5% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white to off-white

color

white to yellow

color

white to off-white

color

white to beige

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

wet ice




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