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SML2527

SW063058

≥98% (HPLC)

Synonym(s):

7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-4-(2-iodobenzoyl)-2H-1,4-benzodiazepin-2-one

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Size/SKUAvailabilityPrice
5 mg
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$115.00
25 mg
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$464.00
$394.40

About This Item

Empirical Formula (Hill Notation):
C22H15BrFIN2O2
CAS Number:
Molecular Weight:
565.17
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$115.00


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Ic1c(cccc1)C(=O)N2C(c4c(ccc(c4)Br)NC(=O)C2)c3ccc(cc3)F

InChI

1S/C22H15BrFIN2O2/c23-14-7-10-19-17(11-14)21(13-5-8-15(24)9-6-13)27(12-20(28)26-19)22(29)16-3-1-2-4-18(16)25/h1-11,21H,12H2,(H,26,28)

InChI key

CFXZDEOFOAXVPQ-UHFFFAOYSA-N

Biochem/physiol Actions

Autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding
SW063058 is an autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding, versus Bax/Bcl-2 binding. SW063058 acts by disrupting the binding of Bcl-2, a negative regulator of autophagy, to the BH3 domain of Beclin 1, which is involved in autophagy initiation. It does not inhibit Bcl-2 binding to the BH3 domain of the pro-apoptotic Bcl-2 family members BAX and BIM. In vitro experiments showed that SW063058 was not cytotoxic and induced autophagy without inducing apoptosis or other forms of cell death.

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This Item
SML0647SML2983SML1134
description

≥98% (HPLC)

description

≥97% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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