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SML2574

Candicidin

≥50% (HPLC)

Synonym(s):

Candicidin, Candeptin, Candimon, Levorin, Vanobid

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Size/SKUAvailabilityPrice
1 mg
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$142.00

About This Item

Empirical Formula (Hill Notation):
C59H84N2O18
CAS Number:
1403-17-4
Molecular Weight:
1109.30
NACRES:
NA.77
UNSPSC Code:
51111800
Form:
solid
Storage condition:
protect from light

$142.00

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biological source

Streptomyces griseus

form

solid

storage condition

protect from light

concentration

≥50% (HPLC)

solubility

DMSO: 1 mg/mL

storage temp.

−20°C

General description

Candicidin is a polyene macrolide antifungal antibiotic which inhibits large number of fungi. 2 Polyene antifungal antibiotics, such as Candicidin, specifically target cell membranes containing sterols. Thus, selectively targets variety of prokaryotic organisms (such as Candida albicans) and not eukaryotic organisms. Candicidin generates cell membrane damage to Candida albicans (C.albicans) by triggering a rapid efflux of K+ ions. Interestingly, it was found that dosage needed for Candicidin to inhibit growth of stationary phase C. albicans cells is 25 μg/ml whereas log-phase C. albicans cells is only 5 μg/mL. In 1953 Kigman and Lewis performed the first in vivo study with mice to reveal the effects of Candicidin. Their study showed that Candicidin exhibits protective effect against C. albicans, Blastomyces dermatitidis and Sporotrichum schenkii but only a partial protective effect against torulosis and histoplasmosis. LD50 for Candicidin oral administration and intraperitoneal administration in mice were 90-400mg/kg and 2.1-7.0 mg/kg respectively. When comparing the activity of Candicidin to other antifungal compounds in vivo protects 100% of mice with C. albicans infection, whereas usage of twice the amount of Nystatin protects only 60% of the mice. Candicidin may undergo a photoisomerization process, yielding all-trans derivatives of Candicidin when exposed to direct UV light.

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475914196000300260
Candicidin ≥50% (HPLC)

Sigma-Aldrich

SML2574

Candicidin

Nystatin, Streptomyces noursei A polyene antifungal antibiotic effective against yeast and mycoplasma.

Sigma-Aldrich

475914

Nystatin, Streptomyces noursei

Bafilomycin A1, Streptomyces griseus

Sigma-Aldrich

196000

Bafilomycin A1, Streptomyces griseus

Diphenyleneiodonium Chloride A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

Sigma-Aldrich

300260

Diphenyleneiodonium Chloride

description

≥50% (HPLC)

description

A polyene antifungal antibiotic effective against yeast and mycoplasma.

description

-

description

A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).

form

solid

form

solid

form

film

form

crystalline solid

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

solubility

DMSO: 1 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 100 μM, ethanol: soluble

solubility

DMSO: 5 mg/mL

concentration

≥50% (HPLC)

concentration

-

concentration

-

concentration

-

biological source

Streptomyces griseus

biological source

-

biological source

-

biological source

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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