Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

SML2604

BAY-885

≥98% (HPLC)

Synonym(s):

BAY 885, BAY885, [2-Amino-4-(trifluoromethoxy)phenyl]{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$218.00
$185.30
25 mg

Available to ship TODAYfromMILWAUKEE

$817.00
$694.45

About This Item

Empirical Formula (Hill Notation):
C25H28F3N7O2
CAS Number:
2307249-33-6
Molecular Weight:
515.53
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32067879
Assay:
≥98% (HPLC)
Form:
powder

$185.30

List Price$218.00Save 15%
Web-Only Promotion

Available to ship TODAYDetails

​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1CCC(CC1)C2=C3C(C=C(C=N3)N4CCN(CC4)C)=NC=N2)C5=CC=C(C=C5N)OC(F)(F)F

InChI

1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3

InChI key

QXURFIGBRGWPQD-UHFFFAOYSA-N

Biochem/physiol Actions

ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor.
BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μM ATP; % inhibition at 1 μM = 62/rat Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4 affinity (20 μM), nor inhibitory potency toward hERG (10 μM) and CYP enzymes (20 μM; CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4). BAY-885 potently inhibits 100 ng/mL EGF-induced, ERK5-dependent MEF2 activity (IC50 = 120 nM; SN12C-MEF2-luc reporter assay).

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML2384SML2382S7071
BAY-885 ≥98% (HPLC)

Sigma-Aldrich

SML2604

BAY-885

BAY 87-2243 ≥98% (HPLC)

Sigma-Aldrich

SML2384

BAY 87-2243

SC75741 ≥97% (HPLC)

Sigma-Aldrich

SML2382

SC75741

SD-208 ≥98% (HPLC), powder

Sigma-Aldrich

S7071

SD-208

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥97% (HPLC)

description

≥98% (HPLC), powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >5 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

off-white to tan

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters