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SML2608

CSRM617 Hydrochloride

≥98% (HPLC)

Synonym(s):

(2,3,4-Trihydroxyphenyl-methylidene)-hydrazino-2-amino-3-hydroxy-1-propanone hydrochloride, 2-Amino-3-hydroxy-N′-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride, 2-[(2,3,4-trihydroxyphenyl)methylene] serinehydrazide hydrochloride (1:1)

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$107.00
$90.95
25 mg

Available to ship TODAYfromMILWAUKEE

$435.00
$369.75

About This Item

Empirical Formula (Hill Notation):
C10H13N3O5 · HCl
CAS Number:
Molecular Weight:
291.69
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

OC1=C(C=CC(O)=C1O)C=NNC(C(CO)N)=O.Cl

InChI key

YBUPSOQAGSOATG-UHFFFAOYSA-N

Biochem/physiol Actions

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 μM) and disrupts OC2 target genes promoter binding. CSRM617 blocks OC2-dependent prostate cancer growth in cultures (IC50 = 4-50 μM; 48 h) via apoptosis induction (fold of untreated annexin V population = 2.3/10 μM, 3.5/20 μM; 22Rv1) and exhibits in vivo efficacy against metastases as well as the growth of established 22Rv1 tumor in mice in vivo (50 mg/kg/day ip.).
HOX domain-targeting ONECUT2 (OC2) inhibitor against OC2-dependent prostate cancer growth in vitro and in vivo.

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This Item
SML1882M9020PZ0250
description

≥98% (HPLC)

description

≥98% (HPLC)

description

-

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

room temp

storage temp.

-

storage temp.

room temp

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

ethanol: 122 mg/mL, H2O: 47 mg/mL, isopropanol: 476 mg/mL, glycerol: 95 mg/mL

solubility

H2O: 20 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

color

white to beige

color

white to beige

color

-

color

white to beige


signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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