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SML2625

RCM-1

≥98% (HPLC)

Synonym(s):

2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile, 2-{[2-Oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-4,6-di(thiophen-2-yl)pyridine-3-carbonitrile

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$100.00
$85.00
25 mg

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$322.00
$273.70

About This Item

Empirical Formula (Hill Notation):
C20H12N2OS4
CAS Number:
Molecular Weight:
424.58
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$85.00

List Price$100.00Save 15%
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Estimated to ship onSeptember 08, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to very dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c(ccc1)c2nc(c(c(c2)c4[s]ccc4)C#N)SCC(=O)c3[s]ccc3

InChI key

DCCYTKKDAZEVLY-UHFFFAOYSA-N

Biochem/physiol Actions

Induces FOXM1 degradation and blocks its nuclear localization, suppresses FOXM1-mediated goblet cell metaplasia and airway hyperresponsiveness in vivo.
RCM-1 is a forkhead box M1 (FOXM1) inhibitor that blocks FOXM1 nuclear localization (IC50 = 720 nM using GFP-FOXM1-expressing U2OS cells) and causes FOXM1 degradation via ubiquitination induction (2.9- and 4.8-fold of basal level in A549 cells with 10 μM or 20 μM RCM-1, respectively) without affecting cellular YAP, FACT140, NF-κB, FOXA2, and FOXJ1 levels. RCM-1 intraperitoneal injection (1.7 mg/kg) in mice downregulates endogenous murine FOXM1 level as well as transgenic human FOXM1 GFP fusion level in vivo, effectively suppressing house dust mite-induced lung inflammation as well as goblet cell metaplasia and airway hyperresponsiveness in response to IL-13.

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This Item
SML0943SML1485SML1563
description

≥98% (HPLC)

description

-

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to very dark orange

color

orange to dark red

color

light yellow to yellow-green

color

white to light brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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