Induces FOXM1 degradation and blocks its nuclear localization, suppresses FOXM1-mediated goblet cell metaplasia and airway hyperresponsiveness in vivo.
RCM-1 is a forkhead box M1 (FOXM1) inhibitor that blocks FOXM1 nuclear localization (IC50 = 720 nM using GFP-FOXM1-expressing U2OS cells) and causes FOXM1 degradation via ubiquitination induction (2.9- and 4.8-fold of basal level in A549 cells with 10 μM or 20 μM RCM-1, respectively) without affecting cellular YAP, FACT140, NF-κB, FOXA2, and FOXJ1 levels. RCM-1 intraperitoneal injection (1.7 mg/kg) in mice downregulates endogenous murine FOXM1 level as well as transgenic human FOXM1 GFP fusion level in vivo, effectively suppressing house dust mite-induced lung inflammation as well as goblet cell metaplasia and airway hyperresponsiveness in response to IL-13.
NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 95092201, mouse kidney, Epithelial-like
assay
≥98% (HPLC)
assay
-
assay
≥98% (HPLC)
assay
-
form
powder
form
lyophilized powder
form
powder
form
-
Quality Level
100
Quality Level
100
Quality Level
100
Quality Level
-
storage temp.
2-8°C
storage temp.
−20°C
storage temp.
-10 to -25°C
storage temp.
−196°C
solubility
DMSO: 2 mg/mL, clear
solubility
-
solubility
DMSO: 2 mg/mL, clear (Warmed)
solubility
-
color
white to very dark orange
color
-
color
white to beige
color
-
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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