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SML2651

Elesclomol

≥98% (HPLC), anticancer agent, powder

Synonym(s):

1,3-bis[2-Methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid, GSK842879A, N′1,N′3-Dimethyl-N′1,N′3-di(phenylcarbonothioyl)malonohydrazide, NSC 174939, NSC174939, STA 4783, STA-4783, STA4783

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$107.00
25 mg

Available to ship TODAYfromMILWAUKEE

$435.00
$369.75

About This Item

Empirical Formula (Hill Notation):
C19H20N4O2S2
CAS Number:
Molecular Weight:
400.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$107.00


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Product Name

Elesclomol, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

S=C(N(NC(=O)CC(=O)NN(C)C(=S)c2ccccc2)C)c1ccccc1

InChI

1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)

InChI key

BKJIXTWSNXCKJH-UHFFFAOYSA-N

Biochem/physiol Actions

Copper (II)-chelating malonohydrazide derivative with in vitro and in vivo anticancer efficacy via reactive oxygen species (ROS) & apoptosis induction.
Elesclomol (STA-4783) is a copper (II)-chelating malonohydrazide derivative that exerts its in vitro and in vivo anticancer efficacy via reactive oxygen species (ROS)/oxidative stress & apoptosis induction in a Cu(II)-dependent manner (GI50 = 12 nM without vs. 129 nM with Cu2+ removal by TRIEN in K562 culture; typical conc. range 0.1-2 μM in cultures). Elesclomol chelates extracellular Cu(II) for mitochondria delivery, where upon Cu2+ reduction (to Cu+) & ROS generation, copper-free elesclomol then exits cells for continual Cu(II) shuttling and accumulation in mitochondria. In addition to Cu2+, elesclomol can also chelate Co2+ and Ni2+, but not Fe3+ or Zn2+.

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This Item
SML1478A2846799718
description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC), solid

description

-

form

powder

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95%

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

H2O: soluble

solubility

-

color

white to beige

color

white to beige

color

off-white to light tan

color

-


Storage Class

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral



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