SML2694
FB23-2
≥98% (HPLC), m6A demethylase inhibitor, powder
Synonym(s):
2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxybenzamide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $182.00 |
25 mg | Check Cart for Availability | $680.00 $578.00 |
About This Item
Empirical Formula (Hill Notation):
C18H15Cl2N3O3
CAS Number:
Molecular Weight:
392.24
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
FB23-2, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=C(NC2=C(C(NO)=O)C=CC=C2)C(Cl)=CC(C3=C(C)ON=C3C)=C1
InChI
1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
InChI key
ILHNIWOZZKIBNW-UHFFFAOYSA-N
Biochem/physiol Actions
FB23-2 is a cell penetrant, potent and specific inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein) that RNA methylation in varies of AML cells. FB23-2 potently inhibits proliferation and promotes apoptosis and differentiation in human acute myeloid leukemia (AML) cells and primary blast AML cells lines and xenografts in mice. It minimally affects proliferation of human normal bone marrow cells.
cell penetrant, potent and specific inhibitor of N6-methyladenosine (m6A) demethylase FTO
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This Item | |
|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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