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SML2698

EVT-101 dihyrochloride

≥98% (HPLC)

Synonym(s):

5-(3-Difluoromethyl-4-fluorophenyl)-3-(2-methylimidazol-1-ylmethyl)pyridazine dihydrochloride, 5-[3-(Difluoromethyl)-4-fluorophenyl]-3-[(2-methyl-1H-imidazol-1-yl)methyl]pyridazine dihydrochloride, EVT 101 dihydrochloride, EVT101 dihydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$125.00
$106.25
25 mg

Available to ship TODAYfromMILWAUKEE

$408.00
$346.80

About This Item

Empirical Formula (Hill Notation):
C16H13F3N4 · 2HCl
CAS Number:
Molecular Weight:
391.22
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)C1=C(F)C=CC(C2=CC(CN3C(C)=NC=C3)=NN=C2)=C1

InChI

1S/C16H13F3N4.2ClH/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19;;/h2-8,16H,9H2,1H3;2*1H

InChI key

OJBLXSPBJMGZDN-UHFFFAOYSA-N

Biochem/physiol Actions

EVT-101 is a potent and orally active NR2B-subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist (IC50 = 17 nM against 5 nM Ro 25-6981 for binding rat brain membrane) that targets the GluN1/GluN2B dimer interface with a distinctly different binding mode as ifenprodil. EVT 101 potently inhibits current induction by Glu/Gly (100 μM each) in rat GluN1-1a/mouse GluN2B co-expressing xenopus in vitro (IC50 = 12 nM) and blocks MK-801 binding in mouse brain in vivo (3 mg EVT-101/kg p.o. & 0.2 μCi [3H]MK-801/g i.v. administered 55 min and 10 min prior to brain removal, respectively).
Potent and orally active NR2B-/GluN2B-subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist with in vitro and in vivo efficacy.

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This Item
SML2784SML2324M4699
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 30 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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