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SML2713

MU1210

≥98% (HPLC)

Synonym(s):

1-Methyl-4-(9-(3-(pyridin-4-yl)-phenyl)-7-oxa-2-aza-bicyclo[4.3.0]nona-1,3,5,8-tetraen-3-yl)-1H-pyrazole, 5-(1-Methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine, VN339

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$145.00
25 mg

Available to ship TODAYfromMILWAUKEE

$447.00

About This Item

Empirical Formula (Hill Notation):
C22H16N4O
CAS Number:
Molecular Weight:
352.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$145.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CN(N=C1)C=C1C2=CC=C3C(C(C4=CC=CC(C5=CC=NC=C5)=C4)=CO3)=N2

InChI

1S/C22H16N4O/c1-26-13-18(12-24-26)20-5-6-21-22(25-20)19(14-27-21)17-4-2-3-16(11-17)15-7-9-23-10-8-15/h2-14H,1H3

InChI key

HEAGNKNMQVIVMM-UHFFFAOYSA-N

Biochem/physiol Actions

ATP site-targeting, potent and selective inhibitor against cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4, and homeodomain-interacting protein kinase 2 (HIPK2), but not CLK3.
MU1210 is a potent and selective inhibitor against cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4 (CLK1/2/4 IC50 = 8/20/12 nM; CLK1/2/4 Ki = 84/91/23 nM by NanoBRET) and HIPK2 (IC50 = 29 nM) with good selectivity over HIPK1/3 (IC50 = 187/159 nM), DYRK1a/1b/2 (IC50 = 213/956/1309 nM), CLK3 (IC50 >3 μM) and 194 other kinases. MU1210 enhances alternative spliced MDM4-S mRNA (10 μM, 24 h) and exhibits antiproliferation activity in MCF7 cultures (IC50 in 72 h = 1.1 μM). Unlike most ATP site-targeting kinase inhibitors, X-ray crystallography shows that MU1210 is anchored to the back pocket instead of the hinge region of CLK1. MU140 serves as a negative control.

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This Item
SML2722SML0333P0036
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >10 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

off-white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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