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SML2728

ML375

≥98% (HPLC)

Synonym(s):

(S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one, (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one, ML 375, VU0483253

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Size/SKUAvailabilityPrice
5 mg
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$107.00
$111.00
25 mg
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$435.00
$369.75

About This Item

Empirical Formula (Hill Notation):
C23H15ClF2N2O2
CAS Number:
1488362-55-5
Molecular Weight:
424.83
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD28411378
Assay:
≥98% (HPLC)
Form:
powder

$111.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -150 to -175, c = 0.5 in chloroform-d

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1c(ccc(c1)C(=O)N2[C@]4(N(CC2)C(=O)c5c4cccc5)c3ccc(cc3)Cl)F

InChI key

GXBAKXRLQAPKEE-QHCPKHFHSA-N

Biochem/physiol Actions

ML375 is an orally active, brain-penetrant, potent and M5 subtype-selective muscarinic acetylcholine receptor (mAChR) negative allosteric modulator (NAM) (IC50 = 300/790 nM against 10 μM NMS-induced Ca2+ mobilization in h/r M5-transfected CHO cells; h/r M1-M4 IC50 >30 μM) that reduces N-methylscopolamine (NMS) ML5 dissociation rate without competing against NMS for receptor binding. M375 shows in vivo efficacy in rat models of substances addiction (cocaine, ethanol, oxycodone) with excellent multispecies pharmacokinetic properties.
Orally active, brain-penetrant, potent & M5-selective muscarinic acetylcholine receptor (mAChR) NAM with in vivo efficacy in rat models of substances addiction.

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This Item
SML1117SML1833
ML375 ≥98% (HPLC)

Sigma-Aldrich

SML2728

ML375

ML345 ≥98% (HPLC)

Sigma-Aldrich

SML1117

ML345

ML385 ≥98% (HPLC)

Sigma-Aldrich

SML1833

ML385

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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