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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $122.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $470.00 $399.50 |
About This Item
Empirical Formula (Hill Notation):
C15H25N5O2 · xHCl · yH2O
Molecular Weight:
307.39 (anhydrous free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
N(CCN(CC)C(=O)CNCc1nccc(c1)C(=O)N)(C)C
InChI key
PNFMVADNCOGWME-UHFFFAOYSA-N
Biochem/physiol Actions
KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.
Selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
| solubility H2O: 2 mg/mL, clear | solubility H2O: ≥10 mg/mL | solubility H2O: 1 mg/mL, clear (warmed) | solubility H2O: ≥5 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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