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SML2802

ATR-101

≥98% (HPLC)

Synonym(s):

1[[1[4(Dimethylamino)phenyl]cyclopentyl]methyl]3[2,6di(propan2yl)phenyl]urea hydrochloride, ATR 101, ATR101, CI-984, N-[2,6-bis(1-Methylethyl)phenyl]-N-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]urea hydrochloride, Nevanimibe HCl, PD 132301 HCl, PD 132301-02, PD 132301-2, PD132301 HCl, PD132301-02, PD132301-2

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Pack SizeSKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
$163.00
25 mg
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$675.00

About This Item

Empirical Formula (Hill Notation):
C27H39N3O·HCl
CAS Number:
133825-81-7
Molecular Weight:
458.08
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00899568
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$163.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Cl-].N(C)(C)c1ccc(cc1)C3(CCCC3)CNC(=O)Nc2c(cccc2C(C)C)C(C)C.[H+]

InChI

1S/C27H39N3O.ClH/c1-19(2)23-10-9-11-24(20(3)4)25(23)29-26(31)28-18-27(16-7-8-17-27)21-12-14-22(15-13-21)30(5)6;/h9-15,19-20H,7-8,16-18H2,1-6H3,(H2,28,29,31);1H

InChI key

SDOOGTHIDFZUNM-UHFFFAOYSA-N

Biochem/physiol Actions

ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) that reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed rat models. In addition, ATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH), and Cushing′s syndrome (CS).
Orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior.

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ATR-101 ≥98% (HPLC)

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PSNCBAM-1 ≥98% (HPLC)

Sigma-Aldrich

SML0298

PSNCBAM-1

TPPU ≥98% (HPLC)

Sigma-Aldrich

SML0750

TPPU

AST487 ≥98% (HPLC)

Sigma-Aldrich

SML2363

AST487

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000321621
0000321621
0000097075
0000097076
0000094265

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Global Trade Item Number

SKUGTIN
SML2802-25MG04061841790945

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