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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Please contact Customer Service for Availability | $180.00 $153.00 | |
| 25 mg | Please contact Customer Service for Availability | $729.00 $619.65 |
About This Item
Empirical Formula (Hill Notation):
C18H22Cl2O5
CAS Number:
Molecular Weight:
389.27
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
$153.00
List Price$180.00Save 15%Web-Only Promotion
Please contact Customer Service for Availability
Product Name
SB-204990, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Clc1c(ccc(c1)Cl)CCCCCC[C@H]2OC(=O)[C@@](C2)(O)CC(=O)O
InChI
1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1
InChI key
YTRNLFYTHYWDAU-KDOFPFPSSA-N
Biochem/physiol Actions
ATP citrate-lyase inhibitor SB-201076 γ-lactone prodrug with cell-permeability, oral availability and in vivo hypocholesterolaemic/hypolipidaemic efficacy.
SB-204990 is a cell-permeable and orally available γ-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (Ki =1 μM against human and rat ACL) in a predominantly competitive manner with a small but significant uncompetitive component. SB-204990 treatment is shown to suppress the rate of cellular cholesterol and fatty acid synthesis in HepG2 cultures (by 91% & 82%, respectively, with 30 μM SB-204990), and display hypocholesterolaemic and hypolipidaemic efficacy in vivo when administered in the diet (0.05-0.25%, w/w; mice, rats, dogs).
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: >5 mg/mL | solubility DMSO: ≥30 mg/mL | solubility H2O: 10 mg/mL, clear (warmed to 60 °C) |
| color white to beige | color white to beige | color white to off-white | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2829-25MG | 04061842318148 |
| SML2829-5MG | 04061842318155 |



