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SML2858

Compound 8918

≥98% (HPLC)

Synonym(s):

1-[(2,6-Diethylphenyl)-3-N-ethylcarbamimodoyl]urea, 8918

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$70.90
25 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$289.00

About This Item

Empirical Formula (Hill Notation):
C14H22N4O
CAS Number:
Molecular Weight:
262.35
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$70.90


Estimated to ship onAugust 17, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

N(CC)C(=N)NC(=O)Nc1c(cccc1CC)CC

InChI key

VHGRQUGTHVVVTE-UHFFFAOYSA-N

Biochem/physiol Actions

Compound 8918 is an orally active, non-cytotoxic, phosphopantethein (Ppt)-binding pocket-targeting, non-competitive M. tuberculosis (Mtb) Ppt transferase (PptT) inhibitor (IC50 = 2.5 μM, Emax 80-90%) that exhibits mycobactericidal activity (MIC90 = 0.56-3 μM/29 clinical Mtb isolates; MBC99 = 6.25 μM/Mtb, 3.13 μM/M. smegmatis) with no bactericidal potency against S. aureus, E. coli, P. aeruginosa, Streptomyces or C. albicans. Oral administration is efficacious against H37Rv replication in mouse lung in vivo (by 100%; 100 mg/kg/d, 4 d/wk for 2 wks). Mutations in MtbH37Rv rv2794c (PptT) or rv279c (Ppt hydrolase, PptH) gene confers 8918 resistance.
Orally active, phosphopantethein (Ppt) pocket-targeting, non-cytotoxic, M. tuberculosis (Mtb) Ppt transferase (PptT) inhibitor with in vitro and in vivo mycobactericidal activity.

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This Item
SML3029SML2884SML0220
description

≥98% (HPLC)

description

>95% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL (clear solution)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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