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SML2901

MAC-545496

≥98% (HPLC)

Synonym(s):

N-(5-chloropyridin-2-ylcarbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$70.90
$60.26
25 mg

Available to ship TODAYfromMILWAUKEE

$289.00
$245.65

About This Item

Empirical Formula (Hill Notation):
C18H18ClN5O3S
CAS Number:
Molecular Weight:
419.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$60.26

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

S=C(Nc3ncc(cc3)Cl)NC(=O)c1cc(c(cc1)N2CCCCC2)[N+](=O)[O-]

InChI

1S/C18H18ClN5O3S/c19-13-5-7-16(20-11-13)21-18(28)22-17(25)12-4-6-14(15(10-12)24(26)27)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H2,20,21,22,25,28)

InChI key

AFOKREIUUQFDNW-UHFFFAOYSA-N

Biochem/physiol Actions

MAC-545496 is a potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR) that displays antivirulence and antimicrobial adjuvant properties. MAC-545496 reverses β-lactam resistance in Methicillin-resistant strains (MRSA) and synergizes with cationic antimicrobial peptides (CAMPs). It also potentiates the effects of Cefuroxime and Oxacillin MRSA strains. MAC-545496 has no effect on commensal S. epidermidis and Gram-negative bacteria such as P. aeruginosa.
potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR); antivirulent, antibacterial

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This Item
SML2809SML0391SML2762
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >5 mg/mL

solubility

DMSO: 2 mg/mL, clear

color

faint yellow to dark orange

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3



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