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SML2909

Nolatrexed dihydrochloride

≥98% (HPLC)

Synonym(s):

2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride, AG 337

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$88.20
$91.40
25 mg

Available to ship TODAYfromMILWAUKEE

$288.00
$244.80

About This Item

Empirical Formula (Hill Notation):
C14H12N4OS · 2HCl
CAS Number:
Molecular Weight:
357.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$91.40

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O

InChI

1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H

InChI key

PJKVJJYMWOCLIJ-UHFFFAOYSA-N

Biochem/physiol Actions

Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.
potent thymidylate synthase inhibitor

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This Item
1500659PHR15961A00610
description

≥98% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

Pharmaceutical Analytical Impurity (PAI)

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-


Pictograms

Health hazard

Signal Word

Warning

Hazard Codes

Hazard Classifications

Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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