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SML2914

EMI1

≥98% (HPLC)

Synonym(s):

3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one, 3-(2-Benzoxazolyl)-7-(diethylamino)coumarin, 3-(Benzoxazol-2-yl)-7-diethylamino-2H-benzopyran-2-one

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Size/SKUAvailabilityPrice
5 mg
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$70.60
$60.01
25 mg
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$288.00
$244.80

About This Item

Empirical Formula (Hill Notation):
C20H18N2O3
CAS Number:
Molecular Weight:
334.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$60.01

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(CC)(CC)c1cc2[o][c](c(cc2cc1)c3nc4c([o]3)cccc4)=O

InChI

1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3

InChI key

UJOQSHCJYVRZKJ-UHFFFAOYSA-N

Biochem/physiol Actions

EMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines.
call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S triple mutants associated with drug-resistant NSCLC

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This Item
SML0273PZ0183SML1944
description

≥98% (HPLC)

description

≥97% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: ≥25 mg/mL

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to tan

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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