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SML2918

INT131

≥98% (HPLC)

Synonym(s):

2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide, AMG-131, T0903131

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Size/SKUAvailabilityPrice
5 mg
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$100.00
$85.00
25 mg
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$322.00
$273.70

About This Item

Empirical Formula (Hill Notation):
C21H12Cl4N2O3S
CAS Number:
Molecular Weight:
514.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$85.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc2cc(c(c(c2)Cl)Oc3cnc4c(c3)cccc4)Cl)c1c(cc(cc1)Cl)Cl

InChI

1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H

InChI key

NMRWDFUZLLQSBN-UHFFFAOYSA-N

Biochem/physiol Actions

INT131 is a brain penetrant, non-thiazolidinedione, highly potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator (SPPARM) that displays anti-diabetic activities. INT131 is a partial, rather than a full agonist of PPARγ, and in clinical trials has shown increased glucose tolerance without the weight gain and cardiovascular side effects seen with some of the full agonist.
Selective PPAR Modulator (SPPARM)

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This Item
SML0784R0658SML0895
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to off-white

color

white to light brown


Storage Class

11 - Combustible Solids



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