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SML2937

iHAP1

≥98% (HPLC)

Synonym(s):

(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone, 2-Chloro-10-(4-methoxybenzoyl)-10H-phenothiazine

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$88.20
$74.97
25 mg

Available to ship TODAYfromMILWAUKEE

$357.00
$303.45

About This Item

Empirical Formula (Hill Notation):
C20H14ClNO2S
CAS Number:
Molecular Weight:
367.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$74.97

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1c2c(cc(cc2)Cl)N(c4c1cccc4)C(=O)c3ccc(cc3)OC

InChI key

CSWHYHPUEDNIQY-UHFFFAOYSA-N

Biochem/physiol Actions

iHAP1 is a potent activator of protein phosphatase 2A (PP2A) that allosterically facilitates assembly and activation of PP2A holoenzyme complex consisting PPP2R1A, PPP2R5E (B56ε, regulatory), and PPP2CA subunits. iHAP1 induces dephosphorylation of MYBL2 transcription factor on Ser241, causing irreversible cell cycle arrest of leukemia and other cancer cells in prometaphase. iHAP1 exhibits significant antitumor activity and lack of toxicity in T-ALL xenograft mice models. Normal CD34+ HSPCs are appears to be resistant to iHAP1. iHAP1 does not inhibit dopamine receptor D2.
potent allosteric activator of protein phosphatase 2A (PP2A) containing regulatory subunit PPP2R5E (B56ε)

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This Item
T8516E5406SML2065
description

≥98% (HPLC)

description

≥99%, powder

description

≥98% (HPLC), powder

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥99%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

ethanol: soluble 5 mg/mL, H2O: soluble 50 mg/mL, clear, colorless to yellow, DMSO: soluble

solubility

DMSO: >5 mg/mL at ~60 °C, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to off-white

color

white

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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