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SML2951

SGC-CK2-1

≥98% (HPLC)

Synonym(s):

N-(5-(3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-methylphenyl)propionamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$157.00
25 mg

Available to ship TODAYfromMILWAUKEE

$504.00

About This Item

Empirical Formula (Hill Notation):
C20H21N7O
CAS Number:
Molecular Weight:
375.43
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$157.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[n]21ncc(c2nc(cc1NC4CC4)Nc3cc(c(cc3)C)NC(=O)CC)C#N

InChI key

YKDZIFFKQUNVHH-UHFFFAOYSA-N

Biochem/physiol Actions

Potent and highly selective casein 2 (CK2, CKII) inhibitor with potent cellular activity, but no antiproliferation efficacy in HCT116 or U-87 MG cancer cultures.
SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α′ IC50 = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC50 = 440 nM, IC50≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α′ IC50 = 36/16 nM by cellular NanoBRET assay).

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This Item
SML0235P0040SML3294
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

solubility

DMSO: >20 mg/mL

solubility

DMSO: 2 mg/mL, clear (Warmed)

color

white to beige

color

white to beige

color

white to off-white

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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